BIN1 Rabbit pAb
Catalog No:AB-A1792
Manufacturer:ABclonal
Synonyms:BIN1;AMPH2;AMPHL;SH3P9
Applications:WB,IHC,IF
Reactivity:Human,Rat
Host:Rabbit
Conjugate:No
€65,00 – €370,00
Product Name: | BIN1 Rabbit pAb |
Category: | Polyclonal Antibodies |
Description: | This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynamin, synaptojanin, endophilin, and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in several transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described. |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 230-409 of human BIN1 (NP_647601.1). |
Gene ID: | 274 |
Swiss prot: | O00499 |
Molecular weight: | 45-64kDa |
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