Western blot analysis of extracts of U-251MG cells, using Beta-TRCP antibody (A1656) at 1:1000 dilution.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% nonfat dry milk in TBST.|Detection: ECL Enhanced Kit (RM00021).|Exposure time: 180s.
Beta-TRCP Rabbit pAb
Catalog No:AB-A1656
Manufacturer:ABclonal
Synonyms:BTRC;BETA-TRCP;FBW1A;FBXW1;FBXW1A;FWD1;bTrCP;bTrCP1;betaTrCP;Beta-TRCP
Applications:WB,IHC,IF
Reactivity:Human,Mouse,Rat
Host:Rabbit
Conjugate:No
€65,00 – €370,00
Product Name: | Beta-TRCP Rabbit pAb |
Category: | Polyclonal Antibodies |
Description: | This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class; in addition to an F-box, this protein contains multiple WD-40 repeats. The encoded protein mediates degradation of CD4 via its interaction with HIV-1 Vpu. It has also been shown to ubiquitinate phosphorylated NFKBIA (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha), targeting it for degradation and thus activating nuclear factor kappa-B. Alternatively spliced transcript variants have been described. A related pseudogene exists in chromosome 6. |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 50-340 of human Beta-TRCP (NP_378663.1). |
Gene ID: | 8945 |
Swiss prot: | Q9Y297 |
Molecular weight: | 65kDa/68kDa |
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