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Western blot analysis of extracts of various cell lines, using Bcl10 Rabbit mAb (A4520) at 1:1000 dilution.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% nonfat dry milk in TBST.|Detection: ECL Basic Kit (RM00020).|Exposure time: 10s.
Bcl10 Rabbit mAb
Catalog No：AB-A4520
Manufacturer：ABclonal
Synonyms：CARMEN, CIPER, CLAP, IMD37, c-E10, mE10
Applications：WB
Reactivity：Human
Host：Rabbit
Conjugate：No
€65,00 – €485,00
| Product Name: | Bcl10 Rabbit mAb |
| Category: | Monoclonal Antibodies |
| Description: | This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016] |
| Immunogen: | A synthesized peptide derived from human Bcl10 |
| Gene ID: | 8915 |
| Swiss prot: | O95999 |
| Molecular weight: | 31kDa |
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