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Western blot analysis of extracts of various cell lines, using ATF6 antibody (A12570) at 1:1000 dilution.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% nonfat dry milk in TBST.|Detection: ECL Basic Kit (RM00020).|Exposure time: 60s.
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Immunohistochemistry of paraffin-embedded human esophagus using ATF6 antibody (A12570) (40x lens).
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Immunohistochemistry of paraffin-embedded rat brain using ATF6 antibody (A12570) (40x lens).
ATF6 Rabbit pAb
Catalog No：AB-A12570
Manufacturer：ABclonal
Synonyms：ATF6;ACHM7;ATF6A
Applications：WB,IHC
Reactivity：Human,Mouse,Rat
Host：Rabbit
Conjugate：No
€65,00 – €325,00
| Product Name: | ATF6 Rabbit pAb |
| Category: | Polyclonal Antibodies |
| Description: | This gene encodes a transcription factor that activates target genes for the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Although it is a transcription factor, this protein is unusual in that it is synthesized as a transmembrane protein that is embedded in the ER. It functions as an ER stress sensor/transducer, and following ER stress-induced proteolysis, it functions as a nuclear transcription factor via a cis-acting ER stress response element (ERSE) that is present in the promoters of genes encoding ER chaperones. This protein has been identified as a survival factor for quiescent but not proliferative squamous carcinoma cells. There have been conflicting reports about the association of polymorphisms in this gene with diabetes in different populations, but another polymorphism has been associated with increased plasma cholesterol levels. This gene is also thought to be a potential therapeutic target for cystic fibrosis. |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 570 to the C-terminus of human ATF6 (NP_031374.2). |
| Gene ID: | 22926 |
| Swiss prot: | P18850 |
| Molecular weight: | 74kDa |
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