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Western blot analysis of extracts of various cell lines, using ASXL1 antibody (A9890) at 1:1000 dilution.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% nonfat dry milk in TBST.|Detection: ECL Basic Kit (RM00020).|Exposure time: 5s.
ASXL1 Rabbit pAb
Catalog No：AB-A9890
Manufacturer：ABclonal
Synonyms：ASXL1;BOPS;MDS
Applications：WB
Reactivity：Human,Mouse
Host：Rabbit
Conjugate：No
€65,00 – €370,00
| Product Name: | ASXL1 Rabbit pAb |
| Category: | Polyclonal Antibodies |
| Description: | This gene is similar to the Drosophila additional sex combs gene, which encodes a chromatin-binding protein required for normal determination of segment identity in the developing embryo. The protein is a member of the Polycomb group of proteins, which are necessary for the maintenance of stable repression of homeotic and other loci. The protein is thought to disrupt chromatin in localized areas, enhancing transcription of certain genes while repressing the transcription of other genes. The protein encoded by this gene functions as a ligand-dependent co-activator for retinoic acid receptor in cooperation with nuclear receptor coactivator 1. Mutations in this gene are associated with myelodysplastic syndromes and chronic myelomonocytic leukemia. Alternative splicing results in multiple transcript variants. |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 70-250 of human ASXL1 (NP_056153.2). |
| Gene ID: | 171023 |
| Swiss prot: | Q8IXJ9 |
| Molecular weight: | 53kDa/165kDa |
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