Topovale [Cas No. 500214-53-9]
Catalog No：TA-T9088
Manufacturer：TargetMol
Synonyms：Topoval,ARC 111,ARC111,ARC-111
CAS No.：500214-53-9
Formula：C23H23N3O5
MWt：421.45
€98,00 – €2.290,00
| Name: | Topovale |
| Category: | Biochemicals |
| Description: | Topovale is a potent inhibitor of topoisomerase I. Topovale inhibits hypoxia-mediated accumulation of hypoxia-inducible factor-1alpha. Topovale exhibited low nM cytotoxicity against a panel of cancer cells. Topovale cytotoxicity as well as Topovale-induced apoptosis was reduced > 100-fold in CPT-resistant topoisomerase I (TOP1)-deficient P388/CPT45 cells as compared with P388 cells. |
| Pathway: | DNA Damage/DNA Repair |
| Target: | Topoisomerase |
| Receptor: | topoisomerase I |
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