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Immunohistochemistry of paraffin-embedded human stomach using MAP3K5 antibody (A3271) (40x lens).
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Immunohistochemistry of paraffin-embedded rat liver using MAP3K5 antibody (A3271) (40x lens).
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Immunohistochemistry of paraffin-embedded human esophagus using MAP3K5 antibody (A3271) (40x lens).
ASK1 Rabbit pAb
Catalog No：AB-A3271
Manufacturer：ABclonal
Synonyms：MAP3K5;ASK1;MAPKKK5;MEKK5
Applications：IHC
Reactivity：Human,Rat
Host：Rabbit
Conjugate：No
€65,00 – €370,00
| Product Name: | ASK1 Rabbit pAb |
| Category: | Polyclonal Antibodies |
| Description: | Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MAPKKK5 contains 1,374 amino acids with all 11 kinase subdomains. Northern blot analysis shows that MAPKKK5 transcript is abundantly expressed in human heart and pancreas. The MAPKKK5 protein phosphorylates and activates MKK4 (aliases SERK1, MAPKK4) in vitro, and activates c-Jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK) during transient expression in COS and 293 cells; MAPKKK5 does not activate MAPK/ERK. |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1173-1374 of human ASK1 (NP_005914.1). |
| Gene ID: | 4217 |
| Swiss prot: | Q99683 |
| Molecular weight: | 69kDa/154kDa |
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