(Arg6)-Amyloid β-Protein (1-40)
Catalog No：CP-AMYD-050A
Manufacturer：CPC Scientific
Size：0.5 mg
CAS No.：N/A
Formula：C194H300 N54O58S
MWt：4,349
€281,00
| Product Name: | (Arg6)-Amyloid 尾-Protein (1- 40) |
| Category: | Peptides |
| Three letter sequence: | Asp-Ala-Glu- Phe-Arg-Arg- Asp-Ser-Gly- Tyr-Glu-Val- His-His-Gln- Lys-Leu-Val- Phe-Phe-Ala- Glu-Asp-Val- Gly-Ser-Asn- Lys-Gly-Ala- Ile-Ile-Gly- Leu-Met-Val- Gly-Gly-Val- Val Trifluoroacet ate salt |
| One letter sequence: | DAEFRRDSGY EVHHQKLVFFA EDVGSNKGAII GLMVGGVV |
| Description: | This peptide is the English (H6R) mutation of 尾- amyloid, which accelerates fibrillation without increasing protofibril formation. The English and Tottori mutations alter A尾 assembly at its earliest stages, monomer folding and oligomerization, and produce oligomers that are more toxic to cultured neuronal cells than are wild type oligomers. The exchange of His6 by Arg influences the structure of the Cu2+ complex formed by A尾 peptides. |
| Literature References: | Y.Hori et al., J. Biol. Chem., 282, 4916 (2007) K.Ono et al., J. Biol. Chem., 285, 23186 (2010) B.Alies et al., Inorg. Chem., 50, 11192 (2011) |
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