Gigantol [Cas No. 67884-30-4]
Catalog No:TA-TL0008
Manufacturer:TargetMol
CAS No.:67884-30-4
Formula:C16H18O4
MWt:274.31
€77,00 – €853,00
Name: | Gigantol |
Category: | Biochemicals |
Description: | Gigantol is a novel inhibitor of the Wnt/β-catenin pathway. It inhibits Wnt/β-catenin signaling through downregulation of phosphorylated LRP6 and cytosolic β-catenin in breast cancer cells. Gigantol may be developed as a promising neuroprotective agent for successful MSC transplantation in ischemic diseases, it shows the protective effect against hydrogen peroxide-induced apoptosis in rat bone marrow mesenchymal stem cells through the PI3K/Akt pathway.Gigantol inhibits aldose reductase gene to exert its anti-cataract activity. Gigantol induces growth inhibition and apoptosis of HepG2 cells via the PI3K/Akt/NF-κB signaling pathway.Gigantol also shows α-glucosidase inhibitory activity. |
Pathway: | Stem Cells, Metabolism |
Target: | Wnt/beta-catenin inhibitor, Glucokinase inhibitor |
Receptor: | β-catenin, α-glucosidase |
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