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Western blot analysis of extracts of 293 cells, using APAF1 antibody (A0751).
APAF1 Rabbit pAb
Catalog No：AB-A0751
Manufacturer：ABclonal
Synonyms：APAF1;APAF-1;CED4
Applications：WB
Reactivity：Human,Mouse
Host：Rabbit
Conjugate：No
€65,00 – €370,00
| Product Name: | APAF1 Rabbit pAb |
| Category: | Polyclonal Antibodies |
| Description: | This gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms. |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human APAF1 (NP_863651.1). |
| Gene ID: | 317 |
| Swiss prot: | O14727 |
| Molecular weight: | 37kDa/133kDa/135kDa/137kDa/140kDa/141kDa |
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