A unique collection of 1059 natural products with known anti-cancer activity for high throughput screening (HTS) and high content screening (HCS);Known bioactivity for all compounds: detailed biological and pharmacological information, providing the research foundation and theoretical direction for screening;Clear source: known active natural products selected from animals, plants, or microorganisms with clear species information;Detailed compound information with structure, solubility, targeted signal pathways, action sites, and biological activity description;Cost-effectiveness: expensive natural products with poor drug likeliness are excluded, allowing for more high-quality natural products at a lower cost.