SKI-178 [Cas No. 1259484-97-3]
Catalog No：TA-T9014
Manufacturer：TargetMol
CAS No.：1259484-97-3
Formula：C21H22N4O4
MWt：394.43
€54,00 – €1.170,00
| Name: | SKI-178 |
| Category: | Biochemicals |
| Description: | SKI-178 is a sphingosine kinase 1 (SphK1) inhibitor with IC50 of 0.1-1.8 μM. It induces prolonged mitosis followed by apoptotic cell death through the intrinsic apoptotic cascade. The sustained activation of CDK1 during prolonged mitosis, mediated by SKI-178 leads to the simultaneous phosphorylation of the prosurvival Bcl-2 family members, Bcl-2 and Bcl-xl, as well as the phosphorylation and subsequent degradation of Mcl-1. |
| Pathway: | Apoptosis,GPCR/G Protein |
| Target: | Apoptosis,S1P Receptor |
| Receptor: | Apoptosis,SphK1,SphK2 |
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