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Western blot analysis of extracts of various cell lines, using ALIX / PDCD6IP antibody (A2215) at 1:1000 dilution.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% nonfat dry milk in TBST.|Detection: ECL Enhanced Kit (RM00021).|Exposure time: 3min.
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Immunohistochemistry of paraffin-embedded rat kidney using ALIX / PDCD6IP antibody (A2215) at dilution of 1:100 (40x lens).
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Immunohistochemistry of paraffin-embedded human prostate using ALIX / PDCD6IP antibody (A2215) at dilution of 1:100 (40x lens).
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Immunohistochemistry of paraffin-embedded human stomach using ALIX / PDCD6IP antibody (A2215) at dilution of 1:100 (40x lens).
ALIX / PDCD6IP Rabbit pAb
Catalog No：AB-A2215
Manufacturer：ABclonal
Synonyms：PDCD6IP;AIP1;ALIX;DRIP4;HP95
Applications：WB,IHC,IF
Reactivity：Human,Mouse,Rat
Host：Rabbit
Conjugate：No
€65,00 – €370,00
| Product Name: | ALIX / PDCD6IP Rabbit pAb |
| Category: | Polyclonal Antibodies |
| Description: | This gene encodes a protein that functions within the ESCRT pathway in the abscission stage of cytokinesis, in intralumenal endosomal vesicle formation, and in enveloped virus budding. Studies using mouse cells have shown that overexpression of this protein can block apoptosis. In addition, the product of this gene binds to the product of the PDCD6 gene, a protein required for apoptosis, in a calcium-dependent manner. This gene product also binds to endophilins, proteins that regulate membrane shape during endocytosis. Overexpression of this gene product and endophilins results in cytoplasmic vacuolization, which may be partly responsible for the protection against cell death. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. Related pseudogenes have been identified on chromosome 15. |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human ALIX / PDCD6IP (NP_037506.2). |
| Gene ID: | 10015 |
| Swiss prot: | Q8WUM4 |
| Molecular weight: | 30kDa/96kDa |
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