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Western blot analysis of extracts of various cell lines, using ACVR2B antibody (A7868) at 1:3000 dilution.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% nonfat dry milk in TBST.|Detection: ECL Basic Kit (RM00020).|Exposure time: 30s.
ACVR2B Rabbit pAb
Catalog No：AB-A7868
Manufacturer：ABclonal
Synonyms：ACVR2B;ACTRIIB;ActR-IIB;HTX4
Applications：WB,IF
Reactivity：Human
Host：Rabbit
Conjugate：No
€65,00 – €370,00
| Product Name: | ACVR2B Rabbit pAb |
| Category: | Polyclonal Antibodies |
| Description: | Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor. |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 50-150 of human ACVR2B (NP_001097.2). |
| Gene ID: | 93 |
| Swiss prot: | Q13705 |
| Molecular weight: | 57kDa |
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