Acetyl- (Nle4,Asp5,D- 2-Nal7,Lys10)-cyclo-α-MSH (4-10) amide
Catalog No:CP-MSH-002B
Manufacturer:CPC Scientific
Size:5 mg
CAS No.:168482-23-3
Formula:C54H71N 15O9
MWt:1,074
€372,00
Product Name: | Acetyl- (Nle4,Asp5,D- 2-Nal7,Lys10)- cyclo-伪-MSH (4-10) amide |
Category: | Peptides |
Three letter sequence: | Ac-Nle- cyclo(-Asp- His-D-2-Nal- Arg-Trp-Lys- NH2) Trifluoroacet ate salt |
One letter sequence: | Ac-Nle-cyclo(- DH-D-2-Nal- RWK-NH2) |
Description: | Screening analogs of the cyclic lactam melanocortin agonist MTII led to the identification of the agoutimimetic SHU9119. The cyclopeptide SHU9119 shares pharmacological properties with the agouti peptide in that it is a potent antagonist of the melanocortin-4 receptor and a less potent antagonist of the melanocortin-3 receptor. |
Literature References: | V.J.Hruby et al., J. Med. Chem., 38, 3454 (1995) W.Fan et al., Nature, 385, 165 (1997) |
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