α-Defensin 6
Catalog No：CP-DEFS-008A
Manufacturer：CPC Scientific
Size：0.1 mg
Formula：C156H228 N46O46S 7
MWt：3,708
€234,00
| Product Name: | 伪-Defensin 6 |
| Category: | Peptides |
| Three letter sequence: | Ala-Phe-Thr- Cys-His-Cys- Arg-Arg-Ser- Cys-Tyr-Ser- Thr-Glu-Tyr- Ser-Tyr-Gly- Thr-Cys-Thr- Val-Met-Gly- Ile-Asn-His- Arg-Phe-Cys- Cys- Leu(Cys4 and Cys31/Cys6 and Cys20/Cys10 and Cys30 Bridge) |
| One letter sequence: | AFTCHCRRSC YSTEYSYGTCT VMGINHRFCCL (Cys4 and Cys31/Cys6 and Cys20/Cys10 and Cys30 Bridge) |
| Description: | Cysteine-rich cationic peptide with antiviral activity against HSV infection and a role in N. gonorrhoeae- mediated HIV enhancement. In contrast to the other members of the 茠- defensin family it shows very low antimicrobial activity against Gram- negative and Gram- positive bacteria. As a biomarker of colon adenocarcinoma it may have utility in colon cancer screening and diagnosis. |
| Literature References: | Z.Wu et al., J. Pept. Res., 64, 118 (2004) M.J.Nam et al., J. Biol. Chem., 280, 8260 (2005) E.Hazrati et al., J. Immunol., 177, 8658 (2006) A.Szyk et al., Protein Sci., 15, 2749 (2006) M.E.Klotman et al., J. Immunol., 180, 6176 (2008) |
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