Featured Ferroptosis Research Tools from ABclonal
A new form of cell death, ferroptosis, was recently discovered. Ferroptosis is an iron-dependent programmed cell death resulting from alterations of metabolic processes and accumulation of lipid peroxidation that is toxic and damaging to the membrane structure. Ferroptosis initiation and execution lies at the intersection of amino acid, lipid, and iron metabolism, but ferroptosis sensitivity is also modulated by several lines of mechanisms, including A) the regulation of GSH and redox homeostasis, such as function of system Xc-, GPX4 regulation, FSP1-CoQ10- NAD(P)H pathway, sulfur transfer pathway, mevalonate (MVA) pathway, glutamine metabolic pathway, NRF2 and p53 regulatory axis; B) the regulation of iron homeostasis, such as the regulation of ATG5-ATG7-NCOA4 pathway, IREB regulation system, and the regulatory pathways of heatshock proteins; C) related enzymes around glucose and lipid metabolism, such as PHGDH, G6PD, ACSL4, and LPCAT3, etc. ; D) mitochondria function regulation, such as VDAC, mitochondrial electron transport chain (ETC) , TCA cycle and glutaminolysis.
Here, we recommend ABclonal featured antibody products against key targets of iron homeostasis and redox regulation, including,
- AB-A5865 TFRC Rabbit pAb
- AB-A11241 Ferritin Light Chain mAb
- AB-A19062 Heme Oxygenase 1 Rabbit mAb
- AB-A5695 [KO Validated] NCOA4 Rabbit pAb
- AB-A11243 GPX4 Rabbit mAb
- AB-A11159 NRF2 Rabbit pAb
- AB-A19586 NQO1 Rabbit mAb
- AB-A12768 PEBP1 Rabbit mAb
- AB-A4252 CD26 Rabbit mAb
- AB-A19701 NOX2/CYBB/gp91phox Rabbit mAb