c-Myc Rabbit pAb
Catalog No:AB-A11394
Manufacturer:ABclonal
Synonyms:MRTL;MYCC;bHLHe39;c-Myc;MYC
Applications:IHC
Reactivity:Mouse,Rat
Host:Rabbit
Conjugate:No
€65,00 – €370,00
Product Name: | c-Myc Rabbit pAb |
Category: | Polyclonal Antibodies |
Description: | The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt’s lymphomas, suggesting its importance in the normal function of this gene. |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 350 to the C-terminus of human c-Myc (NP_002458.2). |
Gene ID: | 4609 |
Swiss prot: | P01106 |
Molecular weight: | 48kDa/50kDa |
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