.jpg)
Western blot analysis of extracts of various cell lines, using GPX4 Rabbit mAb (A11243) at 1：1000 dilution.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% nonfat dry milk in TBST.|Detection: ECL Basic Kit (RM00020).|Exposure time: 10s.
.jpg)
Western blot analysis of extracts from normal (control) and GPX4 knockout U-87MG cell pools, using GPX4 antibody (A11243) at 1:1000 dilution.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% nonfat dry milk in TBST.|Detection: ECL Basic Kit (RM00020).|Exposure time: 1s.
GPX4 Rabbit mAb
Catalog No：AB-A11243
Manufacturer：ABclonal
Synonyms：GPx-4, GSHPx-4, MCSP, PHGPx, SMDS, snGPx, snPHGPx
Applications：WB,IP
Reactivity：Human,Mouse,Rat
Host：Rabbit
Conjugate：No
€65,00 – €485,00
| Product Name: | GPX4 Rabbit mAb |
| Category: | Monoclonal Antibodies |
| Description: | The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of hydrogen peroxide, organic hydroperoxides and lipid hydroperoxides, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme has a high preference for lipid hydroperoxides and protects cells against membrane lipid peroxidation and cell death. It is also required for normal sperm development; thus, it has been identified as a 'moonlighting' protein because of its ability to serve dual functions as a peroxidase, as well as a structural protein in mature spermatozoa. Mutations in this gene are associated with Sedaghatian type of spondylometaphyseal dysplasia (SMDS). This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2016] |
| Immunogen: | A synthesized peptide derived from human GPX4 |
| Gene ID: | 2879 |
| Swiss prot: | P36969 |
| Molecular weight: | 19kDa/22kDa |
Help & Support
Product
Guarantee and
Expert Support
Related products
Catalog No：AB-A6826
Manufacturer：ABclonal
Synonyms：ACSL4;ACS4;FACL4;LACS4;MRX63;MRX68
Applications：WB,IF
Reactivity：Human,Mouse,Rat
Host：Rabbit
Conjugate：No
€65,00 – €370,00
Catalog No：AB-A19020
Manufacturer：ABclonal
Synonyms：CDW44;CSPG8;ECMR-III;HCELL;HUTCH-I;IN;LHR;MC56;MDU2;MDU3;MIC4;Pgp1;CD44;CD44
Applications：WB,IHC
Reactivity：Human
Host：Rabbit
Conjugate：No
€65,00 – €485,00
Catalog No：AB-A0040
Manufacturer：ABclonal
Synonyms：MET;AUTS9;DFNB97;HGFR;RCCP2;c-Met
Applications：WB
Reactivity：Human,Mouse,Rat
Host：Rabbit
Conjugate：No
€65,00 – €370,00
Catalog No：AB-A0027
Manufacturer：ABclonal
Synonyms：CANDF7;IMD31A;IMD31B;IMD31C;ISGF-3;STAT91;STAT1 alpha;STAT1
Applications：WB,IHC
Reactivity：Human,Mouse,Rat
Host：Rabbit
Conjugate：No
€65,00 – €370,00
Catalog No：AB-A0008
Manufacturer：ABclonal
Synonyms：10q23del;BZS;CWS1;DEC;GLM2;MHAM;MMAC1;PTEN1;TEP1;PTEN;PTENbeta
Applications：WB,IHC,IF
Reactivity：Human,Mouse,Rat
Host：Rabbit
Conjugate：No
€65,00 – €370,00
Catalog No：AB-A0003
Manufacturer：ABclonal
Synonyms：OSRC;PPP1R130;RB;p105-Rb;pRb;pp110;RB1;Rb
Applications：WB,IF
Reactivity：Human
Host：Rabbit
Conjugate：No
€65,00 – €485,00