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Western blot analysis of extracts of various cell lines, using VHL antibody (A11240) at 1:1000 dilution.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% nonfat dry milk in TBST.|Detection: ECL Basic Kit (RM00020).|Exposure time: 90s.
VHL Rabbit pAb
Catalog No：AB-A11240
Manufacturer：ABclonal
Synonyms：VHL;HRCA1;RCA1;VHL1;pVHL;PVHL
Applications：WB
Reactivity：Human,Mouse
Host：Rabbit
Conjugate：No
€65,00 – €370,00
| Product Name: | VHL Rabbit pAb |
| Category: | Polyclonal Antibodies |
| Description: | Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed. |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human VHL (NP_937799.1). |
| Gene ID: | 7428 |
| Swiss prot: | P40337 |
| Molecular weight: | 18kDa/19kDa/24kDa |
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