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Immunohistochemistry of paraffin-embedded human lung cancer using Phospho-ATR-T1989 Rabbit pAb (AP1248) at dilution of 1:100 (40x lens).
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Immunohistochemistry of paraffin-embedded mouse lung using Phospho-ATR-T1989 Rabbit pAb (AP1248) at dilution of 1:100 (40x lens).
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Immunohistochemistry of paraffin-embedded rat heart using Phospho-ATR-T1989 Rabbit pAb (AP1248) at dilution of 1:100 (40x lens).
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Western blot analysis of extracts of HeLa cells, using Phospho-ATR-T1989 antibody (AP1248) at 1:1000 dilution.HeLa cells were treated by Hydroxyurea (4 mM) at 37℃ for 20 hours.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% nonfat dry milk in TBST.|Detection: ECL Basic Kit (RM00020).|Exposure time: 180s.
Phospho-ATR-T1989 Rabbit pAb
Catalog No：AB-AP1248
Manufacturer：ABclonal
Synonyms：ATR;FCTCS;FRP1;MEC1;SCKL;SCKL1
Applications：WB,IHC
Reactivity：Human,Mouse,Rat
Host：Rabbit
Conjugate：No
€150,00 – €410,00
| Product Name: | Phospho-ATR-T1989 Rabbit pAb |
| Category: | Phosphorylated Antibodies |
| Description: | The protein encoded by this gene belongs the PI3/PI4-kinase family, and is most closely related to ATM, a protein kinase encoded by the gene mutated in ataxia telangiectasia. This protein and ATM share similarity with Schizosaccharomyces pombe rad3, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This kinase has been shown to phosphorylate checkpoint kinase CHK1, checkpoint proteins RAD17, and RAD9, as well as tumor suppressor protein BRCA1. Mutations of this gene are associated with Seckel syndrome. An alternatively spliced transcript variant of this gene has been reported, however, its full length nature is not known. Transcript variants utilizing alternative polyA sites exist. |
| Immunogen: | A phospho synthetic peptide corresponding to residues surrounding T1989 of Human ATR. |
| Gene ID: | 545 |
| Swiss prot: | Q13535 |
| Molecular weight: | 294kDa/297kDa/301kDa |
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