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Western blot analysis of extracts of HeLa cells, using Phospho-MLKL-S454 antibody (AP1173) at 1:1000 dilution.Hela cells were treated by ATP(5 mM) at 30℃ for 1 hour.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% BSA.|Detection: ECL Enhanced Kit (RM00021).|Exposure time: 180s.
Phospho-MLKL-S454 Rabbit pAb
Catalog No：AB-AP1173
Manufacturer：ABclonal
Synonyms：MLKL; hMLKL; mixed lineage kinase domain-like protein
Applications：WB
Reactivity：Human,Rat
Host：Rabbit
Conjugate：No
€65,00 – €410,00
| Product Name: | Phospho-MLKL-S454 Rabbit pAb |
| Category: | Phosphorylated Antibodies |
| Description: | This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. |
| Immunogen: | A phospho synthetic peptide corresponding to residues surrounding S454 of human MLKL. |
| Gene ID: | 197259 |
| Swiss prot: | Q8NB16 |
| Molecular weight: | 53kDa/54kDa |
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