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Western blot analysis of extracts of 293T cells, using Phospho-ATM-S1981 Rabbit mAb (AP1030) at 1:1000 dilution.293T cells were treated by UV at room temperature for 15-30 minutes.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% BSA.|Detection: ECL Enhanced Kit (RM00021).|Exposure time: 3min.
Phospho-ATM-S1981 Rabbit mAb
Catalog No：AB-AP1030
Manufacturer：ABclonal
Synonyms：AT1, ATA, ATC, ATD, ATDC, ATE, TEL1, TELO1
Applications：WB
Reactivity：Human
Host：Rabbit
Conjugate：No
€65,00 – €325,00
| Product Name: | Phospho-ATM-S1981 Rabbit mAb |
| Category: | Phosphorylated Antibodies |
| Description: | The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. [provided by RefSeq, Aug 2010] |
| Immunogen: | A phospho specific peptide corresponding to residues surrounding S1981 of human ATM |
| Gene ID: | 472 |
| Swiss prot: | Q13315 |
| Molecular weight: | 350kDa |
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