Phospho-CGAS-S291 Rabbit pAb
Catalog No:AB-AP0945
Manufacturer:ABclonal
Synonyms:MB21D1;C6orf150;cGAS;h-cGAS;CGAS
Applications:WB
Reactivity:Mouse
Host:Rabbit
Conjugate:No
€65,00 – €410,00
Product Name: | Phospho-CGAS-S291 Rabbit pAb |
Category: | Phosphorylated Antibodies |
Description: | Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (cGAMP) from ATP and GTP and plays a key role in innate immunity. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production. cGAMP can be transferred from producing cells to neighboring cells through gap junctions, leading to promote TMEM173/STING activation and convey immune response to connecting cells. cGAMP can also be transferred between cells by virtue of packaging within viral particles contributing to IFN-induction in newly infected cells in a cGAS-independent but TMEM173/STING-dependent manner. In addition to antiviral activity, also involved in the response to cellular stresses, such as senescence, DNA damage or genome instability. Acts as a regulator of cellular senescence by binding to cytosolic chromatin fragments that are present in senescent cells, leading to trigger type-I interferon production via TMEM173/STING and promote cellular senescence (By similarity). Acts as a suppressor of DNA repair in response to DNA damage: translocates to the nucleus following dephosphorylation at Tyr-215 and inhibits homologous recombination repair by interacting with PARP1, the CGAS-PARP1 interaction leading to impede the formation of the PARP1-TIMELESS complex. |
Immunogen: | A synthetic phosphorylated peptide around S291 of human CGAS. |
Gene ID: | 115004 |
Swiss prot: | Q8N884 |
Molecular weight: | 59kDa |
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