.jpg)
Western blot analysis of extracts of NIH/3T3 cells, using Phospho-PTEN-S380 antibody (AP0930) at 1:1000 dilution.NIH/3T3 cells were treated by CIP(20uL/400ul) at 37℃ for 1 hour.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% nonfat dry milk in TBST.|Detection: ECL Basic Kit (RM00020).|Exposure time: 1s.
Phospho-PTEN-S380 Rabbit pAb
Catalog No：AB-AP0930
Manufacturer：ABclonal
Synonyms：10q23del;BZS;CWS1;DEC;GLM2;MHAM;MMAC1;PTEN1;TEP1;PTEN;PTENbeta
Applications：WB
Reactivity：Human,Mouse,Rat
Host：Rabbit
Conjugate：No
€65,00 – €410,00
| Product Name: | Phospho-PTEN-S380 Rabbit pAb |
| Category: | Phosphorylated Antibodies |
| Description: | This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded by this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. The use of a non-canonical (CUG) upstream initiation site produces a longer isoform that initiates translation with a leucine, and is thought to be preferentially associated with the mitochondrial inner membrane. This longer isoform may help regulate energy metabolism in the mitochondria. A pseudogene of this gene is found on chromosome 9. Alternative splicing and the use of multiple translation start codons results in multiple transcript variants encoding different isoforms. |
| Immunogen: | A phospho specific peptide corresponding to residues surrounding S380 of human PTEN |
| Gene ID: | 5728 |
| Swiss prot: | P60484 |
| Molecular weight: | 47kDa |
Help & Support
Product
Guarantee and
Expert Support
Related products
Catalog No：AB-AP0020
Manufacturer：ABclonal
Synonyms：CRE-BP1;CREB-2;CREB2;HB16;TREB7;ATF2
Applications：WB,IHC,IF
Reactivity：Human,Mouse,Rat
Host：Rabbit
Conjugate：No
€65,00 – €410,00
Catalog No：AB-AP0011
Manufacturer：ABclonal
Synonyms：BAD;BBC2;BCL2L8;Bad
Applications：WB
Reactivity：Human,Mouse
Host：Rabbit
Conjugate：No
€65,00 – €410,00
Catalog No：AB-AP0010
Manufacturer：ABclonal
Synonyms：BAD;BBC2;BCL2L8;Bad
Applications：WB
Reactivity：Human,Mouse,Rat
Host：Rabbit
Conjugate：No
€65,00 – €410,00
Catalog No：AB-AP0008
Manufacturer：ABclonal
Synonyms：AT1;ATA;ATC;ATD;ATDC;ATE;TEL1;TELO1;ATM
Applications：WB,IF
Reactivity：Human
Host：Rabbit
Conjugate：No
€65,00 – €410,00
Catalog No：AB-AP0005
Manufacturer：ABclonal
Synonyms：AKT2;HIHGHH;PKBB;PKBBETA;PRKBB;RAC-BETA
Applications：WB
Reactivity：Human,Mouse,Rat
Host：Rabbit
Conjugate：No
€65,00 – €410,00
Catalog No：AB-AP0003
Manufacturer：ABclonal
Synonyms：ABL;JTK7;p150;c-ABL;v-abl;CHDSKM;c-ABL1;ABL1;c-Abl;bcr/abl
Applications：WB,IF
Reactivity：Human,Mouse
Host：Rabbit
Conjugate：No
€65,00 – €410,00