Phospho-WWTR1-S89 Rabbit pAb
Catalog No：AB-AP0919
Manufacturer：ABclonal
Synonyms：WW domain-containing transcription regulator protein 1;Transcriptional coactivator with PDZ-binding motif;TAZ;WWTR1
Applications：WB
Reactivity：Human,Mouse,Rat
Host：Rabbit
Conjugate：No
€65,00 – €410,00
| Product Name: | Phospho-WWTR1-S89 Rabbit pAb |
| Category: | Phosphorylated Antibodies |
| Description: | Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. Regulates the nuclear accumulation of SMADS and has a key role in coupling them to the transcriptional machinery such as the mediator complex. Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition. |
| Immunogen: | A synthetic phosphorylated peptide around S89 of human WWTR1. |
| Gene ID: | 25937 |
| Swiss prot: | Q9GZV5 |
| Molecular weight: | 44kDa |
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