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Immunohistochemistry of paraffin-embedded human appendix using Phospho-phospholamban-T17 antibody (AP0910) at dilution of 1:100 (40x lens).
Phospho-PLN-T17 Rabbit pAb
Catalog No：AB-AP0910
Manufacturer：ABclonal
Synonyms：CMD1P;CMH18;PLB;PLN
Applications：WB,IHC
Reactivity：Human,Mouse,Rat
Host：Rabbit
Conjugate：No
€65,00 – €410,00
| Product Name: | Phospho-PLN-T17 Rabbit pAb |
| Category: | Phosphorylated Antibodies |
| Description: | The protein encoded by this gene is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. The encoded protein is a key regulator of cardiac diastolic function. Mutations in this gene are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure, and also familial hypertrophic cardiomyopathy. [provided by RefSeq, Apr 2016] |
| Immunogen: | A phospho specific peptide corresponding to residues surrounding T17 of human PLN |
| Gene ID: | 5350 |
| Swiss prot: | P26678 |
| Molecular weight: | 6kDa |
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