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Immunohistochemistry of paraffin-embedded rat testis using Phospho-RPS6KA5-S376 antibody (AP0800) at dilution of 1:100 (40x lens).
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Immunohistochemistry of paraffin-embedded human gastric cancer using Phospho-RPS6KA5-S376 antibody (AP0800) at dilution of 1:100 (40x lens).
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Immunohistochemistry of paraffin-embedded mouse spleen using Phospho-RPS6KA5-S376 antibody (AP0800) at dilution of 1:100 (40x lens).
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Western blot analysis of extracts of NIH/3T3 cells, using Phospho-RPS6KA5-S376 antibody (AP0800) at 1:2000 dilution. NIH/3T3 cells were treated by Anisomycin (25ug/mL) for 30 minutes.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% BSA.|Detection: ECL Basic Kit (RM00020).|Exposure time: 30s.
Phospho-RPS6KA5-S376 Rabbit pAb
Catalog No：AB-AP0800
Manufacturer：ABclonal
Synonyms：RPS6KA5;MSK1;MSPK1;RLPK
Applications：WB,IHC
Reactivity：Human,Mouse,Rat
Host：Rabbit
Conjugate：No
€65,00 – €410,00
| Product Name: | Phospho-RPS6KA5-S376 Rabbit pAb |
| Category: | Phosphorylated Antibodies |
| Description: | Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factors RELA, STAT3 and ETV1/ER81, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes (PubMed:11909979). Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli (PubMed:11909979). Plays an essential role in the control of RELA transcriptional activity in response to TNF and upon glucocorticoid, associates in the cytoplasm with the glucocorticoid receptor NR3C1 and contributes to RELA inhibition and repression of inflammatory gene expression (PubMed:12628924). In skeletal myoblasts is required for phosphorylation of RELA at ‘Ser-276’ during oxidative stress (PubMed:12628924). In erythropoietin-stimulated cells, is necessary for the ‘Ser-727’ phosphorylation of STAT3 and regulation of its transcriptional potential (PubMed:12763138). Phosphorylates ETV1/ER81 at ‘Ser-191’ and ‘Ser-216’, and thereby regulates its ability to stimulate transcription (PubMed:12569367). Directly represses transcription via phosphorylation of ‘Ser-1’ of histone H2A (PubMed:15010469). Phosphorylates ‘Ser-10’ of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. |
| Immunogen: | A synthetic phosphorylated peptide around S376 of human RPS6KA5 (NP_004746.2). |
| Gene ID: | 9252 |
| Swiss prot: | O75582 |
| Molecular weight: | 61kDa/81kDa/89kDa |
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