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Western blot analysis of extracts of Jurkat cells, using Phospho-Pyk2-Y402 antibody (AP0612) at 1:1000 dilution. Jurkat cells were treated by PMA/TPA (200nM) for 10 minutes.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% BSA.|Detection: ECL Basic Kit (RM00020).|Exposure time: 90s.
Phospho-Pyk2-Y402 Rabbit pAb
Catalog No：AB-AP0612
Manufacturer：ABclonal
Synonyms：PTK2B;CADTK;CAKB;FADK2;FAK2;PKB;PTK;PYK2;RAFTK;Pyk2
Applications：WB
Reactivity：Human
Host：Rabbit
Conjugate：No
€65,00 – €410,00
| Product Name: | Phospho-Pyk2-Y402 Rabbit pAb |
| Category: | Phosphorylated Antibodies |
| Description: | This gene encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Four transcript variants encoding two different isoforms have been found for this gene. |
| Immunogen: | A synthetic phosphorylated peptide around Y402 of human Pyk2 (NP_004094.3). |
| Gene ID: | 2185 |
| Swiss prot: | Q14289 |
| Molecular weight: | 111kDa/115kDa |
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