Phospho-Chk2-T68 Rabbit pAb
Catalog No:AB-AP0590
Manufacturer:ABclonal
Synonyms:CDS1;CHK2;HuCds1;LFS2;PP1425;RAD53;hCds1;CHEK2;Chk2
Applications:WB
Reactivity:Human
Host:Rabbit
Conjugate:No
€65,00 – €410,00
Product Name: | Phospho-Chk2-T68 Rabbit pAb |
Category: | Phosphorylated Antibodies |
Description: | In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53. Also, mutations in this gene are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors. This nuclear protein is a member of the CDS1 subfamily of serine/threonine protein kinases. Several transcript variants encoding different isoforms have been found for this gene. |
Immunogen: | A synthetic phosphorylated peptide around T68 of human Chk2 (NP_009125.1). |
Gene ID: | 11200 |
Swiss prot: | O96017 |
Molecular weight: | 15-38kDa/50-65kDa |
Help & Support
Product
Guarantee and
Expert Support
Related products
Catalog No:AB-AP0020
Manufacturer:ABclonal
Synonyms:CRE-BP1;CREB-2;CREB2;HB16;TREB7;ATF2
Applications:WB,IHC,IF
Reactivity:Human,Mouse,Rat
Host:Rabbit
Conjugate:No
€65,00 – €410,00
Catalog No:AB-AP0018
Manufacturer:ABclonal
Synonyms:CHEK1;CHK1
Applications:WB,IF
Reactivity:Human
Host:Rabbit
Conjugate:No
€65,00 – €410,00
Catalog No:AB-AP0017
Manufacturer:ABclonal
Synonyms:CHEK1;CHK1
Applications:WB,IHC,IF
Reactivity:Human,Mouse,Rat
Host:Rabbit
Conjugate:No
€65,00 – €410,00
Catalog No:AB-AP0011
Manufacturer:ABclonal
Synonyms:BAD;BBC2;BCL2L8;Bad
Applications:WB
Reactivity:Human,Mouse
Host:Rabbit
Conjugate:No
€65,00 – €410,00
Catalog No:AB-AP0005
Manufacturer:ABclonal
Synonyms:AKT2;HIHGHH;PKBB;PKBBETA;PRKBB;RAC-BETA
Applications:WB
Reactivity:Human,Mouse,Rat
Host:Rabbit
Conjugate:No
€65,00 – €410,00
Catalog No:AB-AP0004
Manufacturer:ABclonal
Synonyms:AKT;CWS6;PKB;PKB-ALPHA;PRKBA;RAC;RAC-ALPHA;AKT1
Applications:WB,IF
Reactivity:Human
Host:Rabbit
Conjugate:No
€65,00 – €410,00