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Western blot analysis of extracts from HeLa cells, using Phospho-LIMK2-T505 antibody (AP0388).|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% BSA.
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Immunohistochemistry of paraffin-embedded human breast carcinoma using Phospho-LIMK2-T505 antibody (AP0388).
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Immunofluorescence analysis of methanol-fixed HeLa cells using Phospho-LIMK2-T505 antibody (AP0388).
Phospho-LIMK2-T505 Rabbit pAb
Catalog No：AB-AP0388
Manufacturer：ABclonal
Synonyms：LIMK2
Applications：WB,IHC,IF
Reactivity：Human,Mouse,Rat
Host：Rabbit
Conjugate：No
€150,00 – €410,00
| Product Name: | Phospho-LIMK2-T505 Rabbit pAb |
| Category: | Phosphorylated Antibodies |
| Description: | There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. The protein encoded by this gene is phosphorylated and activated by ROCK, a downstream effector of Rho, and the encoded protein, in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. It is thought that this pathway contributes to Rho-induced reorganization of the actin cytoskeleton. At least three transcript variants encoding different isoforms have been found for this gene. |
| Immunogen: | A phospho specific peptide corresponding to residues surrounding T505 of human LIMK2 |
| Gene ID: | 3985 |
| Swiss prot: | P53671 |
| Molecular weight: | 69kDa/72kDa/77kDa |
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