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Western blot analysis of extracts from HeLa cells using Phospho-Bcl-XL-S62 antibody (AP0314).|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% BSA.
Phospho-Bcl-XL-S62 Rabbit pAb
Catalog No：AB-AP0314
Manufacturer：ABclonal
Synonyms：BCL2L1;BCL-XL/S;BCL2L;BCLX;Bcl-X;PPP1R52;BCL2 like 1;Bcl-XL
Applications：WB,IHC,IF
Reactivity：Human,Mouse,Rat
Host：Rabbit
Conjugate：No
€150,00 – €410,00
| Product Name: | Phospho-Bcl-XL-S62 Rabbit pAb |
| Category: | Phosphorylated Antibodies |
| Description: | The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Alternative splicing results in multiple transcript variants encoding two different isoforms. The longer isoform acts as an apoptotic inhibitor and the shorter isoform acts as an apoptotic activator. |
| Immunogen: | A phospho specific peptide corresponding to residues surrounding S62 of human Bcl-XL |
| Gene ID: | 598 |
| Swiss prot: | Q07817 |
| Molecular weight: | 18kDa/25-26kDa |
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