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Western blot analysis of extracts from mouse brain tissue using Phospho-GluR2/GRIA2-S880 antibody (AP0257) and the same antibody preincubated with blocking peptide.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% BSA.
Phospho-GluR2/GRIA2-S880 Rabbit pAb
Catalog No：AB-AP0257
Manufacturer：ABclonal
Synonyms：GRIA2;GLUR2;GLURB;GluA2;GluR-K2;HBGR2
Applications：WB
Reactivity：Human,Mouse,Rat
Host：Rabbit
Conjugate：No
€150,00 – €410,00
| Product Name: | Phospho-GluR2/GRIA2-S880 Rabbit pAb |
| Category: | Phosphorylated Antibodies |
| Description: | Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, GRIA1-4. The subunit encoded by this gene (GRIA2) is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca(2+). Human and animal studies suggest that pre-mRNA editing is essential for brain function, and defective GRIA2 RNA editing at the Q/R site may be relevant to amyotrophic lateral sclerosis (ALS) etiology. Alternative splicing, resulting in transcript variants encoding different isoforms, (including the flip and flop isoforms that vary in their signal transduction properties), has been noted for this gene. |
| Immunogen: | A phospho specific peptide corresponding to residues surrounding S880 of human GluR2/GRIA2 |
| Gene ID: | 2891 |
| Swiss prot: | P42262 |
| Molecular weight: | 93kDa/98kDa/100kDa |
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