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Western blot analysis of extracts from Jurkat cells, using phospho-VAV1-Y174 antibody (AP0180).|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% BSA.
Phospho-VAV1-Y174 Rabbit pAb
Catalog No：AB-AP0180
Manufacturer：ABclonal
Synonyms：VAV1;VAV
Applications：WB
Reactivity：Human,Rat
Host：Rabbit
Conjugate：No
€150,00 – €410,00
| Product Name: | Phospho-VAV1-Y174 Rabbit pAb |
| Category: | Phosphorylated Antibodies |
| Description: | This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. The encoded protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. The encoded protein has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. |
| Immunogen: | A phospho specific peptide corresponding to residues surrounding Y174 of human VAV1 |
| Gene ID: | 7409 |
| Swiss prot: | P15498 |
| Molecular weight: | 94kDa/98kDa |
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