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Immunohistochemistry of paraffin-embedded human breast carcinoma using Phospho-MEK2-T394 antibody (AP0121).
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Immunofluorescence analysis of methanol-fixed HeLa cells using Phospho-MEK2-T394 antibody (AP0121).
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Western blot analysis of extracts from HepG2 cells using Phospho-MEK2-T394 antibody (AP0121).|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% BSA.
Phospho-MEK2-T394 Rabbit pAb
Catalog No：AB-AP0121
Manufacturer：ABclonal
Synonyms：CFC4;MAPKK2;MEK2;MKK2;PRKMK2;MAP2K2
Applications：WB,IHC,IF
Reactivity：Human
Host：Rabbit
Conjugate：No
€150,00 – €410,00
| Product Name: | Phospho-MEK2-T394 Rabbit pAb |
| Category: | Phosphorylated Antibodies |
| Description: | The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene. |
| Immunogen: | A phospho specific peptide corresponding to residues surrounding T394 of human MEK2 |
| Gene ID: | 5605 |
| Swiss prot: | P36507 |
| Molecular weight: | 44kDa |
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