Phospho-MDM2-S260 Rabbit pAb
Catalog No:AB-AP0074
Manufacturer:ABclonal
Synonyms:MDM2;ACTFS;HDMX;hdm2
Applications:WB
Reactivity:Human
Host:Rabbit
Conjugate:No
€65,00 – €410,00
Product Name: | Phospho-MDM2-S260 Rabbit pAb |
Category: | Phosphorylated Antibodies |
Description: | This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells. |
Immunogen: | A synthetic phosphorylated peptide around S260 of human MDM2 (NP_001354919.1). |
Gene ID: | 4193 |
Swiss prot: | Q00987 |
Molecular weight: | 11-14kDa/24-55kDa |
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