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Immunofluorescence analysis of MCF-7 cells using Phospho-Chk1-S280 antibody (AP0017). Blue: DAPI for nuclear staining.
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Western blot analysis of extracts of HT-29 cells, using Phospho-Chk1-Ser280 antibody (AP0017) at 1:1000 dilution.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% BSA.
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Immunohistochemistry of paraffin-embedded rat heart using Phospho-Chk1-S280 antibody (AP0017) at dilution of 1:100 (40x lens).
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Immunohistochemistry of paraffin-embedded human placenta using Phospho-Chk1-S280 antibody (AP0017) at dilution of 1:100 (40x lens).
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Immunohistochemistry of paraffin-embedded mouse brain using Phospho-Chk1-S280 antibody (AP0017) at dilution of 1:100 (40x lens).
Phospho-Chk1-S280 Rabbit pAb
Catalog No：AB-AP0017
Manufacturer：ABclonal
Synonyms：CHEK1;CHK1
Applications：WB,IHC,IF
Reactivity：Human,Mouse,Rat
Host：Rabbit
Conjugate：No
€65,00 – €410,00
| Product Name: | Phospho-Chk1-S280 Rabbit pAb |
| Category: | Phosphorylated Antibodies |
| Description: | The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks. Several alternatively spliced transcript variants have been found for this gene. |
| Immunogen: | A synthetic phosphorylated peptide around S280 of human Chk1 (NP_001265.2). |
| Gene ID: | 1111 |
| Swiss prot: | O14757 |
| Molecular weight: | 43kDa/50kDa/54kDa |
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