Western blot analysis of extracts of various cell lines, using GCH1 antibody (A10616) at 1:1000 dilution.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% nonfat dry milk in TBST.|Detection: ECL Basic Kit (RM00020).|Exposure time: 90s.
GCH1 Rabbit pAb
Catalog No:AB-A10616
Manufacturer:ABclonal
Synonyms:GCH1;DYT14;DYT5;DYT5a;GCH;GTP-CH-1;GTPCH1;HPABH4B
Applications:WB
Reactivity:Human,Mouse,Rat
Host:Rabbit
Conjugate:No
€65,00 – €370,00
Product Name: | GCH1 Rabbit pAb |
Category: | Polyclonal Antibodies |
Description: | This gene encodes a member of the GTP cyclohydrolase family. The encoded protein is the first and rate-limiting enzyme in tetrahydrobiopterin (BH4) biosynthesis, catalyzing the conversion of GTP into 7,8-dihydroneopterin triphosphate. BH4 is an essential cofactor required by aromatic amino acid hydroxylases as well as nitric oxide synthases. Mutations in this gene are associated with malignant hyperphenylalaninemia and dopa-responsive dystonia. Several alternatively spliced transcript variants encoding different isoforms have been described; however, not all variants give rise to a functional enzyme. |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human GCH1 (NP_000152.1). |
Gene ID: | 2643 |
Swiss prot: | P30793 |
Molecular weight: | 23kDa/25kDa/27kDa |
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