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Western blot analysis of extracts of various cell lines, using KCNJ3 antibody (A9824) at 1:1000 dilution.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% nonfat dry milk in TBST.|Detection: ECL Enhanced Kit (RM00021).|Exposure time: 10s.
KCNJ3 Rabbit pAb
Catalog No：AB-A9824
Manufacturer：ABclonal
Synonyms：KCNJ3;GIRK1;KGA;KIR3.1
Applications：WB,IHC
Reactivity：Human,Mouse,Rat
Host：Rabbit
Conjugate：No
€65,00 – €370,00
| Product Name: | KCNJ3 Rabbit pAb |
| Category: | Polyclonal Antibodies |
| Description: | Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and plays an important role in regulating heartbeat. It associates with three other G-protein-activated potassium channels to form a heteromultimeric pore-forming complex that also couples to neurotransmitter receptors in the brain and whereby channel activation can inhibit action potential firing by hyperpolarizing the plasma membrane. These multimeric G-protein-gated inwardly-rectifying potassium (GIRK) channels may play a role in the pathophysiology of epilepsy, addiction, Down’s syndrome, ataxia, and Parkinson’s disease. Alternative splicing results in multiple transcript variants encoding distinct proteins. |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 50-150 of human KCNJ3 (NP_002230.1). |
| Gene ID: | 3760 |
| Swiss prot: | P48549 |
| Molecular weight: | 26kDa/56kDa |
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