Western blot analysis of extracts of various cell lines, using FEN-1 Rabbit mAb (A8999) at 1:1000 dilution.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% nonfat dry milk in TBST.|Detection: ECL Basic Kit (RM00020).|Exposure time: 1s.
FEN-1 Rabbit mAb
Catalog No:AB-A8999
Manufacturer:ABclonal
Synonyms:FEN-1, MF1, RAD2
Applications:WB,IHC
Reactivity:Human,Mouse
Host:Rabbit
Conjugate:No
€65,00 – €485,00
Product Name: | FEN-1 Rabbit mAb |
Category: | Monoclonal Antibodies |
Description: | The protein encoded by this gene removes 5' overhanging flaps in DNA repair and processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis. Direct physical interaction between this protein and AP endonuclease 1 during long-patch base excision repair provides coordinated loading of the proteins onto the substrate, thus passing the substrate from one enzyme to another. The protein is a member of the XPG/RAD2 endonuclease family and is one of ten proteins essential for cell-free DNA replication. DNA secondary structure can inhibit flap processing at certain trinucleotide repeats in a length-dependent manner by concealing the 5' end of the flap that is necessary for both binding and cleavage by the protein encoded by this gene. Therefore, secondary structure can deter the protective function of this protein, leading to site-specific trinucleotide expansions. [provided by RefSeq, Jul 2008] |
Immunogen: | A synthesized peptide derived from human FEN-1 |
Gene ID: | 2237 |
Swiss prot: | P39748 |
Molecular weight: | 42kDa |
Help & Support
Product
Guarantee and
Expert Support
Related products
Catalog No:AB-A0137
Manufacturer:ABclonal
Synonyms:TERF1;PIN2;TRBF1;TRF;TRF1;hTRF1-AS;t-TRF1
Applications:WB,IHC
Reactivity:Human,Mouse
Host:Rabbit
Conjugate:No
€65,00 – €370,00
Catalog No:AB-A0102
Manufacturer:ABclonal
Synonyms:FOXO3;AF6q21;FKHRL1;FKHRL1P2;FOXO2;FOXO3A
Applications:WB,IHC,IF
Reactivity:Human,Mouse,Rat
Host:Rabbit
Conjugate:No
€65,00 – €370,00
Catalog No:AB-A0056
Manufacturer:ABclonal
Synonyms:HEL-215;HEL-S-54e;PHB1;PHB;Prohibitin
Applications:WB,IF
Reactivity:Human,Mouse,Rat
Host:Rabbit
Conjugate:No
€65,00 – €370,00
Catalog No:AB-A0040
Manufacturer:ABclonal
Synonyms:MET;AUTS9;DFNB97;HGFR;RCCP2;c-Met
Applications:WB
Reactivity:Human,Mouse,Rat
Host:Rabbit
Conjugate:No
€65,00 – €370,00
Catalog No:AB-A0052
Manufacturer:ABclonal
Synonyms:MGMT
Applications:WB
Reactivity:Human,Rat
Host:Rabbit
Conjugate:No
€65,00 – €370,00
Catalog No:AB-A0033
Manufacturer:ABclonal
Synonyms:TNFRSF1A;CD120a;FPF;TBP1;TNF-R;TNF-R-I;TNF-R55;TNFAR;TNFR1;TNFR55;TNFR60;p55;p55-R;p60
Applications:IF
Reactivity:Human
Host:Rabbit
Conjugate:No
€65,00 – €370,00