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Western blot analysis of extracts of various cell lines, using TAX1BP3 antibody (A8750) at 1:1000 dilution.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% nonfat dry milk in TBST.|Detection: ECL Basic Kit (RM00020).|Exposure time: 90s.
TAX1BP3 Rabbit pAb
Catalog No：AB-A8750
Manufacturer：ABclonal
Synonyms：TAX1BP3;TIP-1;TIP1
Applications：WB
Reactivity：Human,Mouse
Host：Rabbit
Conjugate：No
€65,00 – €370,00
| Product Name: | TAX1BP3 Rabbit pAb |
| Category: | Polyclonal Antibodies |
| Description: | This gene encodes a small, highly conserved protein with a single PDZ domain. PDZ (PSD-95/Discs large/ZO-1 homologous) domains promote protein-protein interactions that affect cell signaling, adhesion, protein scaffolding, and receptor and ion transporter functions. The encoded protein interacts with a large number of target proteins that play roles in signaling pathways; for example, it interacts with Rho A and glutaminase L and also acts as a negative regulator of the Wnt/beta-catenin signaling pathway. This protein was first identified as binding to the T-cell leukaemia virus (HTLV1) Tax oncoprotein. Overexpression of this gene has been implicated in altered cancer cell adhesion, migration and metastasis. The encoded protein also modulates the localization and density of inwardly rectifying potassium channel 2.3 (Kir2.3). To date, this protein has been shown to play a role in cell proliferation, development, stress response, and polarization. Alternative splicing results in multiple transcript variants encoding distinct isoforms. |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-124 of human TAX1BP3 (NP_055419.1). |
| Gene ID: | 30851 |
| Swiss prot: | O14907 |
| Molecular weight: | 13kDa |
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