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Western blot analysis of extracts of various cell lines, using GNE antibody (A8570) at 1:1000 dilution.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% nonfat dry milk in TBST.|Detection: ECL Basic Kit (RM00020).|Exposure time: 10s.
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Immunohistochemistry of paraffin-embedded mouse brain using GNE antibody (A8570) at dilution of 1:100 (40x lens).
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Immunohistochemistry of paraffin-embedded human esophagus using GNE antibody (A8570) at dilution of 1:100 (40x lens).
GNE Rabbit pAb
Catalog No：AB-A8570
Manufacturer：ABclonal
Synonyms：GNE;DMRV;GLCNE;IBM2;NM;Uae1
Applications：WB,IHC
Reactivity：Human,Mouse,Rat
Host：Rabbit
Conjugate：No
€65,00 – €370,00
| Product Name: | GNE Rabbit pAb |
| Category: | Polyclonal Antibodies |
| Description: | The protein encoded by this gene is a bifunctional enzyme that initiates and regulates the biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. It is a rate-limiting enzyme in the sialic acid biosynthetic pathway. Sialic acid modification of cell surface molecules is crucial for their function in many biologic processes, including cell adhesion and signal transduction. Differential sialylation of cell surface molecules is also implicated in the tumorigenicity and metastatic behavior of malignant cells. Mutations in this gene are associated with sialuria, autosomal recessive inclusion body myopathy, and Nonaka myopathy. Alternative splicing of this gene results in transcript variants encoding different isoforms. |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-150 of human GNE (NP_001121699.1). |
| Gene ID: | 10020 |
| Swiss prot: | Q9Y223 |
| Molecular weight: | 66kDa/71kDa/78kDa/79kDa/83kDa |
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