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Western blot analysis of extracts of various cell lines, using Rap1GAP antibody (A10539) at 1:1000 dilution.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% nonfat dry milk in TBST.|Detection: ECL Basic Kit (RM00020).|Exposure time: 5s.
Rap1GAP Rabbit pAb
Catalog No：AB-A10539
Manufacturer：ABclonal
Synonyms：RAP1GAP;RAP1GA1;RAP1GAP1;RAP1GAPII;RAPGAP
Applications：WB
Reactivity：Human
Host：Rabbit
Conjugate：No
€65,00 – €370,00
| Product Name: | Rap1GAP Rabbit pAb |
| Category: | Polyclonal Antibodies |
| Description: | This gene encodes a type of GTPase-activating-protein (GAP) that down-regulates the activity of the ras-related RAP1 protein. RAP1 acts as a molecular switch by cycling between an inactive GDP-bound form and an active GTP-bound form. The product of this gene, RAP1GAP, promotes the hydrolysis of bound GTP and hence returns RAP1 to the inactive state whereas other proteins, guanine nucleotide exchange factors (GEFs), act as RAP1 activators by facilitating the conversion of RAP1 from the GDP- to the GTP-bound form. In general, ras subfamily proteins, such as RAP1, play key roles in receptor-linked signaling pathways that control cell growth and differentiation. RAP1 plays a role in diverse processes such as cell proliferation, adhesion, differentiation, and embryogenesis. Alternative splicing results in multiple transcript variants encoding distinct proteins. |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 508-727 of human Rap1GAP (NP_001139130.1). |
| Gene ID: | 5909 |
| Swiss prot: | P47736 |
| Molecular weight: | 73kDa/75kDa/76kDa/80kDa |
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