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Western blot analysis of extracts of various cell lines, using ARHGEF3 antibody (A8490) at 1:1000 dilution.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% nonfat dry milk in TBST.|Detection: ECL Basic Kit (RM00020).|Exposure time: 60s.
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Immunohistochemistry of paraffin-embedded mouse brain using ARHGEF3 antibody (A8490) at dilution of 1:100 (40x lens).
ARHGEF3 Rabbit pAb
Catalog No：AB-A8490
Manufacturer：ABclonal
Synonyms：ARHGEF3;GEF3;STA3;XPLN
Applications：WB,IHC
Reactivity：Human,Mouse
Host：Rabbit
Conjugate：No
€65,00 – €370,00
| Product Name: | ARHGEF3 Rabbit pAb |
| Category: | Polyclonal Antibodies |
| Description: | Rho-like GTPases are involved in a variety of cellular processes, and they are activated by binding GTP and inactivated by conversion of GTP to GDP by their intrinsic GTPase activity. Guanine nucleotide exchange factors (GEFs) accelerate the GTPase activity of Rho GTPases by catalyzing their release of bound GDP. This gene encodes a guanine nucleotide exchange factor, which specifically activates two members of the Rho GTPase family: RHOA and RHOB, both of which have a role in bone cell biology. It has been identified that genetic variation in this gene plays a role in the determination of bone mineral density (BMD), indicating the implication of this gene in postmenopausal osteoporosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 287-526 of human ARHGEF3 (NP_062455.1). |
| Gene ID: | 50650 |
| Swiss prot: | Q9NR81 |
| Molecular weight: | 36kDa/59kDa/60kDa/63kDa |
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