Western blot analysis of extracts of various cell lines, using DNA Polymerase gamma antibody (A8451) at 1:1000 dilution.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% nonfat dry milk in TBST.|Detection: ECL Basic Kit (RM00020).|Exposure time: 3s.
DNA Polymerase gamma Rabbit pAb
Catalog No:AB-A8451
Manufacturer:ABclonal
Synonyms:POLG;MDP1;MIRAS;MTDPS4A;MTDPS4B;PEO;POLG1;POLGA;SANDO;SCAE
Applications:WB
Reactivity:Human
Host:Rabbit
Conjugate:No
€65,00 – €370,00
Product Name: | DNA Polymerase gamma Rabbit pAb |
Category: | Polyclonal Antibodies |
Description: | Mitochondrial DNA polymerase is heterotrimeric, consisting of a homodimer of accessory subunits plus a catalytic subunit. The protein encoded by this gene is the catalytic subunit of mitochondrial DNA polymerase. The encoded protein contains a polyglutamine tract near its N-terminus that may be polymorphic. Defects in this gene are a cause of progressive external ophthalmoplegia with mitochondrial DNA deletions 1 (PEOA1), sensory ataxic neuropathy dysarthria and ophthalmoparesis (SANDO), Alpers-Huttenlocher syndrome (AHS), and mitochondrial neurogastrointestinal encephalopathy syndrome (MNGIE). Two transcript variants encoding the same protein have been found for this gene. |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 980-1239 of human DNA Polymerase gamma (NP_002684.1). |
Gene ID: | 5428 |
Swiss prot: | P54098 |
Molecular weight: | 139kDa |
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