Western blot analysis of extracts of A-549 cells, using DMPK antibody (A10442) at 1:1000 dilution.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% nonfat dry milk in TBST.|Detection: ECL Basic Kit (RM00020).|Exposure time: 5s.
DMPK Rabbit pAb
Catalog No:AB-A10442
Manufacturer:ABclonal
Synonyms:DMPK;DM;DM1;DM1PK;DMK;MDPK;MT-PK
Applications:WB
Reactivity:Human
Host:Rabbit
Conjugate:No
€65,00 – €370,00
Product Name: | DMPK Rabbit pAb |
Category: | Polyclonal Antibodies |
Description: | The protein encoded by this gene is a serine-threonine kinase that is closely related to other kinases that interact with members of the Rho family of small GTPases. Substrates for this enzyme include myogenin, the beta-subunit of the L-type calcium channels, and phospholemman. The 3′ untranslated region of this gene contains 5-38 copies of a CTG trinucleotide repeat. Expansion of this unstable motif to 50-5,000 copies causes myotonic dystrophy type I, which increases in severity with increasing repeat element copy number. Repeat expansion is associated with condensation of local chromatin structure that disrupts the expression of genes in this region. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 350-590 of human DMPK (NP_004400.4). |
Gene ID: | 1760 |
Swiss prot: | Q09013 |
Molecular weight: | 59kDa/60kDa/65kDa/67kDa/69kDa/70kDa |
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