Western blot analysis of extracts of various cell lines, using ACVR1 antibody (A7542) at 1:1000 dilution.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% nonfat dry milk in TBST.|Detection: ECL Enhanced Kit (RM00021).|Exposure time: 90s.
ACVR1 Rabbit pAb
Catalog No:AB-A7542
Manufacturer:ABclonal
Synonyms:ACVR1;ACTRI;ACVR1A;ACVRLK2;ALK2;FOP;SKR1;TSRI
Applications:WB
Reactivity:Human,Mouse
Host:Rabbit
Conjugate:No
€65,00 – €370,00
Product Name: | ACVR1 Rabbit pAb |
Category: | Polyclonal Antibodies |
Description: | Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia ossificans progressive. |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-125 of human ACVR1 (NP_001096.1). |
Gene ID: | 90 |
Swiss prot: | Q04771 |
Molecular weight: | 57kDa |
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