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Western blot analysis of extracts of various cell lines, using ORP150/GRP170/HSP12A Rabbit mAb (A1042) at 1:1000 dilution.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% nonfat dry milk in TBST.|Detection: ECL Basic Kit (RM00020).|Exposure time: 1s.
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Immunohistochemistry of paraffin-embedded rat pancreas using ORP150/GRP170/HSP12A Rabbit mAb (A1042) at dilution of 1:100 (40x lens).
ORP150/GRP170/HSP12A Rabbit mAb
Catalog No：AB-A1042
Manufacturer：ABclonal
Synonyms：GRP-170, Grp170, HSP12A, ORP-150, ORP150
Applications：WB,IHC
Reactivity：Human,Mouse,Rat
Host：Rabbit
Conjugate：No
€65,00 – €485,00
| Product Name: | ORP150/GRP170/HSP12A Rabbit mAb |
| Category: | Monoclonal Antibodies |
| Description: | The protein encoded by this gene belongs to the heat shock protein 70 family. This gene uses alternative transcription start sites. A cis-acting segment found in the 5' UTR is involved in stress-dependent induction, resulting in the accumulation of this protein in the endoplasmic reticulum (ER) under hypoxic conditions. The protein encoded by this gene is thought to play an important role in protein folding and secretion in the ER. Since suppression of the protein is associated with accelerated apoptosis, it is also suggested to have an important cytoprotective role in hypoxia-induced cellular perturbation. This protein has been shown to be up-regulated in tumors, especially in breast tumors, and thus it is associated with tumor invasiveness. This gene also has an alternative translation initiation site, resulting in a protein that lacks the N-terminal signal peptide. This signal peptide-lacking protein, which is only 3 amino acids shorter than the mature protein in the ER, is thought to have a housekeeping function in the cytosol. In rat, this protein localizes to both the ER by a carboxy-terminal peptide sequence and to mitochondria by an amino-terminal targeting signal. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014] |
| Immunogen: | A synthesized peptide derived from human ORP150/GRP170/HSP12A |
| Gene ID: | 10525 |
| Swiss prot: | Q9Y4L1 |
| Molecular weight: | 150kDa |
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