Western blot analysis of extracts of NCI-H460 cells, using ATR Antibody (A7247) at 1:1000 dilution.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% nonfat dry milk in TBST.|Detection: ECL Basic Kit (RM00020).|Exposure time: 60s.
ATR Rabbit pAb
Catalog No:AB-A7247
Manufacturer:ABclonal
Synonyms:ATR;FCTCS;FRP1;MEC1;SCKL;SCKL1
Applications:WB
Reactivity:Human
Host:Rabbit
Conjugate:No
€65,00 – €370,00
Product Name: | ATR Rabbit pAb |
Category: | Polyclonal Antibodies |
Description: | The protein encoded by this gene belongs the PI3/PI4-kinase family, and is most closely related to ATM, a protein kinase encoded by the gene mutated in ataxia telangiectasia. This protein and ATM share similarity with Schizosaccharomyces pombe rad3, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This kinase has been shown to phosphorylate checkpoint kinase CHK1, checkpoint proteins RAD17, and RAD9, as well as tumor suppressor protein BRCA1. Mutations of this gene are associated with Seckel syndrome. An alternatively spliced transcript variant of this gene has been reported, however, its full length nature is not known. Transcript variants utilizing alternative polyA sites exist. |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1400-1500 of human ATR (NP_001175.2). |
Gene ID: | 545 |
Swiss prot: | Q13535 |
Molecular weight: | 294kDa/297kDa/301kDa |
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