Western blot analysis of extracts of various cell lines, using HERPUD1 antibody (A7048) at 1:1000 dilution.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% nonfat dry milk in TBST.|Detection: ECL Basic Kit (RM00020).|Exposure time: 90s.
HERPUD1 Rabbit pAb
Catalog No:AB-A7048
Manufacturer:ABclonal
Synonyms:HERPUD1;HERP;Mif1;SUP
Applications:WB
Reactivity:Human,Mouse,Rat
Host:Rabbit
Conjugate:No
€65,00 – €370,00
Product Name: | HERPUD1 Rabbit pAb |
Category: | Polyclonal Antibodies |
Description: | The accumulation of unfolded proteins in the endoplasmic reticulum (ER) triggers the ER stress response. This response includes the inhibition of translation to prevent further accumulation of unfolded proteins, the increased expression of proteins involved in polypeptide folding, known as the unfolded protein response (UPR), and the destruction of misfolded proteins by the ER-associated protein degradation (ERAD) system. This gene may play a role in both UPR and ERAD. Its expression is induced by UPR and it has an ER stress response element in its promoter region while the encoded protein has an N-terminal ubiquitin-like domain which may interact with the ERAD system. This protein has been shown to interact with presenilin proteins and to increase the level of amyloid-beta protein following its overexpression. Alternative splicing of this gene produces multiple transcript variants encoding different isoforms. The full-length nature of all transcript variants has not been determined. |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human HERPUD1 (NP_055500.1). |
Gene ID: | 9709 |
Swiss prot: | Q15011 |
Molecular weight: | 26kDa/40kDa/43kDa |
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